壊滅 （カイメツ） destruction, annihilation, devastation, catastrophe

潰瘍 （カイヨウ） ulcer

全壊 （ゼンカイ） complete destruction

擂潰 （ライカイ） grinding

潰す （つぶす） to smash, to crush, to flatten, to shut down, to put out of business, to force (a company) to close up shop, to wreck, to break, to block, to thwart, to butcher, to slaughter, to kill (livestock, for food), to kill (time), to while away (the time), to use up (one's time), to waste (e.g. talents)

潰れる （つぶれる） to be crushed, to be smashed, to be broken, to collapse, to become useless, to cease functioning, to be wasted (e.g. time), to go bankrupt, to go out of business, to fail

潰える （ついえる） to fall apart, to collapse, to become useless, to be completely defeated (in battle), to be wiped out, to fall apart (one's body or health)